Centre de recherche sur les Ions, les MAtériaux et la Photonique (UMR 6252)

ARIA is a team dedicated to hadron-biology research in basic and applied sciences for improving radiation-therapy protocols considering both tumor and healthy tissue effects. The ARIA team also operates the experimental radiation-biology platform, with the beam lines and irradiation devices operated by CIMAP, allowing an access to the international research communities to perform radiation-biology studies at GANIL.

The benefit of better ballistic and high efficiency of proton and carbon ions for cancer treatment was demonstrated since decades. However, if the better ballistic of protontherapy is already successfully used worldwide, hadrontherapy with carbon ions stays underused and raises some concerns about likely side effects for patients.

Our pre-clinical and fundamental studies in hadronbiology focus on DNA damage signaling, DNA repair, stress response and the advantages of high LET radiation against radioresistant cancer cells and cancer stem cells.

Our team is organized around two major axis :

Axe 1 : Prof. Siamak Haghdoost
Impact of high/low LET radiation on oxidative stress response, senescence and differentiation process of cancer stem cells as well as primary stem cells, and searching for new biomarkers of individual sensitivity to radiotherapy. Here we use gene-editing approches as well as molecular inhibitor to overcome the radioresistance.

Axe 2 : Dr. François Chevalier
Impact of high LET radiations on radioresistant cancer cells, role of hypoxia and radiosensitisation with dedicated inhibitors ; Non-targeted effects in hadron-therapy